生物标志物 生物标志物
1Korea University College of Medicine, Seoul, Seoul, Korea, Republic of (South); Korea University College of Medicine, Seoul, Korea, Republic of (South).
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
聚焦超声波 (FUS) 在阿尔茨海默病患者中多次安全地打开了血脑屏障 (BBB),在大多数患者中减少了粉样β斑块,并改善了神经精神症状. 这项研究表明,FUS BBB打开是一个有前途的独立疗法.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
- 放射学 放射学是一门学科.
背景情况:
- 聚焦超声波 (FUS) 可以打开阿尔茨海默病 (AD) 患者的血脑屏障 (BBB).
- 最佳的FUS治疗间隔和临床益处的治疗次数是未知的.
研究的目的:
- 为了评估在AD患者中重复的,基于间隔的FUS介导的BBB开口的安全性和有效性.
- 评估治疗后粉样β (Aβ) 斑块和神经精神病症状的变化.
主要方法:
- 一项开放的前性研究,涉及6名阿尔茨海默病患者.
- 三个FUS介导的BBB开幕会议,每隔2个月针对双边前额叶.
- 治疗前后的18F-florbetabenPET扫描和神经心理学/神经精神病学评估.
主要成果:
- 所有6名参与者完成了这项研究,没有任何急性不良事件.
- 平均BBB开口体积为43.1厘米3,明显大于之前的研究.
- 67%的参与者表现出Aβ斑块的减少; 83%的参与者表现出神经精神症状的改善.
结论:
- 在AD患者中,通过FUS重复,广泛的双边前部BBB开口是安全有效的.
- 这是第一个仅通过BBB打开证明神经精神病症状改善的试验.
- FUS BBB开口显示了作为AD的独立治疗策略的潜力.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516