生物标志物 生物标志物
Si Won Ryoo1,2, William Z Lin2, Myuri Ruthirakuhan1,2
1University of Toronto, Toronto, ON, Canada.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
氨酸 (LA) 衍生的可溶性环氧化酶 (sEH) 二醇与2型糖尿病 (T2DM) 中大脑小血管疾病和白质损伤的增加有关. 准sEH可能为减轻与糖尿病相关的神经血管损伤提供治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 代谢障碍 代谢障碍 代谢障碍
- 生物化学 生物化学
背景情况:
- 多不和脂肪酸被代谢成抗炎性环氧化物,但可溶性环氧化酶 (sEH) 将它们转化为细胞毒性二醇.
- 临酸 (LA) 衍生二醇的增加与中风患者的2型糖尿病 (T2DM) 和白质超强度 (WMH) 的认知衰退相关.
- 在T2DM中,LA衍生的二醇和神经成像标记物的关系仍然未被探索.
研究的目的:
- 研究LA衍生的二醇与大脑小血管疾病 (SVD) 标记物和T2DM患者白质完整性之间的关联.
- 探索sEH在糖尿病相关神经血管损伤中的潜在作用.
主要方法:
- 在T2DM参与者的血清中用超高性能液态染色体质谱学量化了两种非化的LA衍生二醇 (9,10-DiHOME和12,13-DiHOME).
- 通过结构和扩散张力MRI评估大脑小血管疾病标志物 (周周血管空间,WMH,缺口性心脏病发作) 和白质完整性 (微分异型,平均扩散性).
- 采用多个线性回归分析,控制相关的人口,临床和遗传因素,并对多个比较进行Bonferroni校正.
主要成果:
- 9,10-DiHOME与较高的WMH和缺口性心脏病发作体积有关,并且增加了平均扩散率 (MD).
- 12,13-DiHOME与WMH体积增加有关.
- 探索性分析揭示了二醇和WMH,内心梗塞和表皮叶的MD之间的关联,9,10-DiHOME也与较低分数异性质 (FA) 相关.
结论:
- 来自LA的sEH二醇与糖尿病患者中大脑小血管疾病病理和白质微观结构损伤的增加显著相关.
- 在糖尿病的背景下,sEH抑制为预防或治疗神经血管和白质损伤提供了一个有希望的治疗途径.
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