生物标志物 生物标志物
Srinivasan Vairavan1, Alankar Atreya2, Nicholas Cummins3
1Janssen Research and Development, Titusville, NJ, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
在阿尔茨海默病 (AD) 诊断之前,言语变化就会出现. 讲故事任务中的声学标记显示了在临床前和临床前阶段早期发现AD的潜力,有助于临床试验.
科学领域:
- 神经学 神经学
- 语音语言病理学 语言病理学
- 生物标志物 生物标志物
背景情况:
- 阿尔茨海默氏病 (AD) 之前,有几十年的言语和语言变化.
- 频繁语音评估的数字工具为早期AD临床试验提供了前景.
- 在RADAR-AD研究中,研究了不同AD (ATN) 阶段的故事叙述任务中的声学语音标记.
研究的目的:
- 评估声学语音标记器在检测阿尔茨海默病 (AD) 早期症状方面的实用性.
- 在AD的综合症阶段内分析与粉样蛋白 (A), (T) 和神经退行 (N) 状态相关的语音模式.
- 评估语音标记在改善AD临床试验查方面的潜力.
主要方法:
- 与四组159名参与者进行的横截面研究:健康对照 (HC),临床前AD (临床前AD). 亚丁病),前期性亚丁病 (大约约) AD) 和轻度的AD.
- 通过使用12种欧洲语言的Mezurio智能手机应用程序通过基于语音的故事叙述任务 (Story Time) 收集的语音样本.
- 线性混合效应模型用于分析语音数据,将参与者,故事和语言视为随机效应,人口学变量视为固定效应.
主要成果:
- 临床前的AD (A+T+) 与对照组相比显示出明显较低的关节率.
- 生产性AD (A+T+) 也表现出较低的发音率,以及语音速度,声音和语音特征的差异.
- 产生性AD (A+T-) 在动和发声段中显示出显著的差异.
结论:
- 话语流的微妙,陶驱动的变化可以在阿尔茨海默病的临床前阶段就被检测出来.
- 声学语音标志物显示出在AD临床试验中增强查的潜力.
- 这项研究得到了创新药品倡议联合企业 (赠款第806999号) 的支持.
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