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临床表现 临床表现

Nurul Izzati Ahmad Fadzuli1, Siong Meng Lim1, Abu Bakar Abdul Majeed2

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科学领域:

  • 微生物组研究的研究.
  • 老年学是一门学科.
  • 心理神经免疫学 心理神经免疫学

背景情况:

  • 老龄化与生理和心理变化有关,包括老年人中孤独,焦虑和抑郁的增加.
  • 肠道微生物群的组成随着年龄的增长而变化,新出现的证据将心理社会因素与肠道疾病联系起来.
  • 肠道功能障碍与与年龄有关的认知衰退有关,这突出了研究心理社会因素与肠道微生物组之间的相互作用的必要性.

研究的目的:

  • 调查心理社会因素 (孤独,焦虑,抑郁) 与老年人肠道微生物群组成之间的关系.
  • 在老年人群中识别与不同年龄组和心理社会状态相关的特定微生物种群.
  • 探索潜在的肠-大脑轴机制影响健康结果在衰老.

主要方法:

  • 招募65岁及以上的社区居民.
  • 对127个便样本进行16S rRNA基因测序,以分析肠道微生物群的组成.
  • 使用GraphPad Prism 9.0和R软件进行统计分析以确定相关性.

主要成果:

  • 在较年轻 (65-74岁) 和较年长 (≥75岁) 的年龄组之间观察到细菌类 (Actinobacteriota, Firmicutes, Proteobacteria) 和属的显著差异.
  • 梅加斯菲拉 (Megasphaera),菌 (Faecalibacterium) 和菌 (Ligilactobacillus) 属与孤独,抑郁和焦虑有显著的负面相关性.
  • 蛋白质细菌是一种失生症标志物,在≥75岁的年龄组中较高,而有益细菌在65-74岁的年龄组中更为丰富.

结论:

  • 老龄化会破坏肠道微生物群的平衡,心理社会因素在调节其组成方面发挥着重要作用.
  • 鉴定的微生物模式及其与心理社会状态的相关性表明,老年人肠道健康和心理健康之间存在联系.
  • 需要进一步的研究来探索这些肠道微生物群变化的健康影响以及微生物修复疗法的潜在益处.