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Updated: May 5, 2026

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
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人工多域体合成和翻译后修改的酶,用于Farnesylated库的生成

Noel Lacerna1, Eric W Schmidt1

  • 1Department of Medicinal Chemistry, College of Pharmacy, University of Utah, Salt Lake City, Utah 84112, United States.

ACS synthetic biology
|December 26, 2025
PubMed
概括

研究人员开发了一种强大的方法来创建用于药物发现的大型类图书馆. 这种系统有效地产生具有异oprenoid 修饰的宏环,在产生新型化合物方面取得了超过 40% 的成功.

关键词:
这就是RiPPs.青巴克的使用方法循环类图书馆 循环类图书馆聚变蛋白质的融合蛋白质酸法纳西化 酸法纳西化蛋白质工程工程 蛋白质工程

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Upstream Processing01:27

Upstream Processing

Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
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