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Updated: Jan 7, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

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合成4'-C-α-Aminoethoxy-2'-O-Methyl-5-Methyl-和5-Propynyl-Uridine胺酸,用于结构优化的反意义寡核酸

Elsayed M Mahmoud1,2, Yoshihito Ueno1,3,4,5

  • 1Course of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.

Current protocols
|December 26, 2025
PubMed
概括

这项研究详细介绍了改进的新型4'-C-α-aminoethoxy (4'AEo) 修饰尿素构建块的合成方法. 这些进步有助于创建下一代具有增强治疗功能的反感性寡核酸 (ASO).

关键词:
4′-C-改性核化物.在RNase H激活过程中,索诺加希拉-哈吉哈拉交叉合反感的寡核化物.化学修饰是一种化学修饰.氧化时发生氧化作用.核酶耐药性 核酶耐药性胺酸的合成方法

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