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临床表现 临床表现

Jackson C Thompson1, Jessie Fanglu Fu1,2, Michelle E Farrell3

  • 1Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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概括
此摘要是机器生成的。

像DCTclock这样的数字认知评估显示出早期阿尔茨海默病 (AD) 变化检测的希望. 纵向研究显示,DCTclock捕获了关于粉样蛋白传播的独特信息,而PACC在晚期认知衰退方面仍然优越.

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科学领域:

  • 神经科学是一个神经科学.
  • 老年学是一门学科.
  • 生物医学工程 生物医学工程

背景情况:

  • 数字认知评估为早期发现阿尔茨海默病 (AD) 病理学提供了潜力.
  • 粉样β (Ab) 传播的空间范围 (EXT) 可能对早期的Ab负担比传统措施更敏感.
  • 以前的横截面数据将恶化的数字时钟绘图测试 (DCTclock) 性能与认知正常 (CN) 个体中的粉样蛋白和蛋白联系在一起.

研究的目的:

  • 纵向评估粉样蛋白扩散 (EXT) 和脑内与认知衰退在认知正常的老年人之间的关系.
  • 评估数字时钟绘图测试 (DCTclock) 在捕捉与临床前阿尔茨海默病相关的早期认知变化的实用性.

主要方法:

  • 195名认知正常的老年人每年接受DCT时钟和PACC5评估,长达6年.
  • 在基线测量时测量了粉样蛋白PET ([11C]匹兹堡化合物B) 和内分泌PET (Flortaucipir SUVR).
  • 用空间范围 (EXT) 来量化 Amyloid 的分布,将参与者分为 EXT,EXT+ 和 EXT++ 组.

主要成果:

  • 与EXT-组相比,EXT+和EXT++组的个体在PACC5和DCT时钟信息处理子评分 (DCT-IP) 上表现出明显更快的认知衰退.
  • 升高的内分泌和粉样蛋白扩散 (EXT+/EXT++) 独立地预测了更快的PACC5衰退.
  • 在EXT+组中,DCT-IP下降速度更快是显著的,这表明对早期粉样蛋白传播的敏感性.

结论:

  • 纵向DCT时钟评估为在粉样蛋白传播的早期阶段对认知衰退提供了独特的见解.
  • 在较晚的临床前AD阶段,PACC仍然是评估与粉样蛋白和蛋白病理相关的严重认知衰退的更强有力的措施.