在性结肠炎中跳过早餐和戒除类固醇:日本的一项基于人口的研究
Hiroshi Fukuda1, Haru Miyagi1, Kenta Yamamoto1
1Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan.
Physiological reports
|December 26, 2025
概括
跳过早餐可能会阻碍性结肠炎 (UC) 患者的缓解. 这项研究发现,经常跳过早餐的UC患者不实现类固醇戒断的几率更高,这表明食时间影响疾病管理.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 时间生物学与健康
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,患病率正在上升.
- 目前的UC治疗侧重于药理学,但饮食时间等生活方式因素未得到充分探索.
- 跳过早餐对UC病程和治疗结果的影响仍然不清楚.
研究的目的:
- 在性结肠炎 (UC) 患者中调查跳过早餐和类固醇戒断之间的关联.
- 探索饮食时间在实现UC持续缓解中的潜在作用.
- 在日本的一大批UC患者中分析饮食时间习惯.
主要方法:
- 使用JMDC数据库 (2015-2023) 进行的回顾性队列研究,数据来自817万个人的数据.
- 确定了1645名UC患者开始接受皮质类固醇治疗,并跟踪至少3年.
- 定义跳过早餐是跳过>3次/周;主要结局是类固醇戒断 (停用皮质类固醇).
主要成果:
- 18.4%的UC患者报告跳过早餐.
- 总体而言,在33.0%的患者中发生了类固醇戒断.
- 在调整其他药物后,跳过早餐与更高的类固醇戒断几率 (OR 1.52,95% CI 1.08-2.14) 有关.
结论:
- 饮食时间,特别是跳过早餐,可能会对性结肠炎 (UC) 的持续缓解产生负面影响.
- 这些发现强调了饮食时间作为UC管理中可修改的因素的潜在重要性.
- 需要对慢性营养和IBD进行进一步的研究来证实这些关联.
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