临床表现 临床表现
Diane M Jacobs1,2, Tyler R Bell3,4, Nathan Whitsel4
1Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
视觉短期记忆结合 (VSTMB) 的微妙认知下降与主观认知下降 (SCD) 的老年人中减少的脑位 (LC) 完整性有关. 这表明LC完整性对于保持认知效率至关重要,甚至在传统阿尔茨海默病标志物出现之前.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 老年学是指老年学的学科.
背景情况:
- 视觉短期记忆结合 (VSTMB) 对皮质连接和早期阿尔茨海默病 (AD) 指标至关重要.
- 在主观认知衰退 (SCD) 个体中观察到VSTMB的障碍,神经心理测试结果正常.
- 在早期的AD tau积累中涉及的正面中位点coeruleus (LC) 的完整性降低与SCD有关.
研究的目的:
- 调查VSTMB,主观认知衰退 (SCD) 和认知不受损的老年人脑部位 (LC) 完整性之间的关联.
- 为了确定VSTMB性能,特别是形状-颜色结合 (SCB),是否与LC完整性和自我报告的认知衰退有关.
- 在早期临床前AD指标的背景下,探索LC完整性在维持认知效率方面的作用.
主要方法:
- 利用了来自越南时代双胞胎老龄化研究 (N=350) 的数据,包括VSTMB任务 (形状-颜色结合与仅形状结合),LC敏感的MRI扫描和日常认知 (ECog) 尺度.
- 使用混合模型分析VSTMB准确性,对LC完整性 (LC-CNR) 和ECog评级进行回归性能,控制认知和心理因素.
- 包括敏感性分析,调整全球神经心理表现,以确保调查结果的可靠性.
主要成果:
- VSTMB准确性在形状-颜色结合 (SCB) 条件下较低,而不是仅在形状 (SO),特别是在更高的设置大小.
- 较高的参与者评级SCD与相对于SO准确度的SCB准确度降低相关.
- 下面的正面-中间LC完整性 (LC-CNR) 与较差的SCB精度相对于SO精度有关,独立于全球认知功能.
结论:
- 在VSTMB中微妙的认知效率损失与SCD相关,并在认知不受损的老年人中降低了LC完整性.
- 脑的完整性可能对保持认知效率至关重要,可能会补偿早期衰退,直到补偿能力被超越.
- 这些发现突显了LC完整性,SCD和VSTMB之间的联系,表明了超越标准神经心理测试的潜在早期临床前AD标志物.
相关概念视频
Chronic Kidney Disease II: Clinical Manifestations
520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations
299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis
364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations
436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management
652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies
437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437


