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临床表现 临床表现

Diane M Jacobs1,2, Tyler R Bell3,4, Nathan Whitsel4

  • 1Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.

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概括
此摘要是机器生成的。

视觉短期记忆结合 (VSTMB) 的微妙认知下降与主观认知下降 (SCD) 的老年人中减少的脑位 (LC) 完整性有关. 这表明LC完整性对于保持认知效率至关重要,甚至在传统阿尔茨海默病标志物出现之前.

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科学领域:

  • 神经科学是一个神经科学.
  • 认知心理学 认知心理学
  • 老年学是指老年学的学科.

背景情况:

  • 视觉短期记忆结合 (VSTMB) 对皮质连接和早期阿尔茨海默病 (AD) 指标至关重要.
  • 在主观认知衰退 (SCD) 个体中观察到VSTMB的障碍,神经心理测试结果正常.
  • 在早期的AD tau积累中涉及的正面中位点coeruleus (LC) 的完整性降低与SCD有关.

研究的目的:

  • 调查VSTMB,主观认知衰退 (SCD) 和认知不受损的老年人脑部位 (LC) 完整性之间的关联.
  • 为了确定VSTMB性能,特别是形状-颜色结合 (SCB),是否与LC完整性和自我报告的认知衰退有关.
  • 在早期临床前AD指标的背景下,探索LC完整性在维持认知效率方面的作用.

主要方法:

  • 利用了来自越南时代双胞胎老龄化研究 (N=350) 的数据,包括VSTMB任务 (形状-颜色结合与仅形状结合),LC敏感的MRI扫描和日常认知 (ECog) 尺度.
  • 使用混合模型分析VSTMB准确性,对LC完整性 (LC-CNR) 和ECog评级进行回归性能,控制认知和心理因素.
  • 包括敏感性分析,调整全球神经心理表现,以确保调查结果的可靠性.

主要成果:

  • VSTMB准确性在形状-颜色结合 (SCB) 条件下较低,而不是仅在形状 (SO),特别是在更高的设置大小.
  • 较高的参与者评级SCD与相对于SO准确度的SCB准确度降低相关.
  • 下面的正面-中间LC完整性 (LC-CNR) 与较差的SCB精度相对于SO精度有关,独立于全球认知功能.

结论:

  • 在VSTMB中微妙的认知效率损失与SCD相关,并在认知不受损的老年人中降低了LC完整性.
  • 脑的完整性可能对保持认知效率至关重要,可能会补偿早期衰退,直到补偿能力被超越.
  • 这些发现突显了LC完整性,SCD和VSTMB之间的联系,表明了超越标准神经心理测试的潜在早期临床前AD标志物.