临床表现 临床表现
Jorge Alcina1, Nikole A Bonillas Félix1, Randy Medrano1
1Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
轻度行为障碍 (MBI) 症状,特别是动机下降,与老年拉丁裔的功能困难有关. 对这些神经精神病症状的早期评估对这一群体至关重要.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 拉丁裔面临着患阿尔茨海默氏症和相关痴呆症 (ADRD) 的更高风险.
- 轻度行为障碍 (MBI) 在50岁以上的成年人中涉及新的神经精神症状,与认知能力下降和功能负担有关.
- 在拉丁裔人群中,MBI-认知关系的研究不足.
研究的目的:
- 调查MBI严重程度和功能障碍在认知无障碍,社区居住的老拉丁裔中之间的关联.
- 探索特定的MBI领域 (兴趣/动机/驱动和情绪/焦虑) 对日常工作的影响.
主要方法:
- 来自波士顿拉丁裔老龄化研究 (BLAST) 的126名认知正常的老拉丁裔 (≥55岁) 参与了这项研究.
- 使用了轻度行为障碍检查清单 (MBI-C) 自我报告和功能活动问卷 (FAQ) 告密者报告.
- 回归模型分析了MBI-C域对FAQ分数的影响,控制年龄,性别,教育和全球认知 (MMSE).
主要成果:
- 在MBI-C兴趣/动机/驱动 (IMD) 领域的更高得分与更大的功能障碍 (FAQ得分) 有显著的关联.
- MBI-C情绪/焦虑 (MA) 域得分没有显示与功能障碍有显著的关联.
- 少数人 (20%) 报告了临床上显著的抑郁症状.
结论:
- 降低动机,MBI的一个组成部分,与在认知不受损的老拉丁裔日常生活中增加的功能负担有关.
- 神经心理症状,特别是与激励相关的症状,在老年拉丁裔成年人中进行评估和管理.
- 需要对更大,更多样化的样本进行进一步的纵向研究,以了解少数群体中这些功能影响.
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