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临床表现 临床表现

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概括
此摘要是机器生成的。

血p-tau217对阿尔茨海默氏症 (AD) 诊断具有前景. 蒙特利尔认知评估 - 泰国版 (MoCA-泰国) 和MoCA-记忆指数得分 (MoCA-MIS) 的新截止分数有助于在泰国检测AD病理.

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科学领域:

  • 神经学 神经学
  • 生物标志物 生物标志物
  • 认知评估 认知评估

背景情况:

  • 血p-tau217是一种新兴的阿尔茨海默病 (AD) 生物标志物,提供了更容易获得的诊断替代品.
  • 像MoCA-Thai和MMSE-Thai这样的认知查工具在临床环境中至关重要,但它们用于识别AD病理的最佳截止分数,特别是与血生物标志物,在LMIC中不清楚.
  • 这项研究调查了MoCA-Thai,MoCA-MIS和MMSE-Thai与血p-tau217一起用于AD诊断的实用性.

研究的目的:

  • 评估MoCA-泰国,MoCA-MIS和MMSE-泰国用于阿尔茨海默病 (AD) 的诊断性能,使用血p-tau217.
  • 为了确定这些认知测试的最佳切断分数,以确定AD病理.
  • 评估将认知查与血生物标志物相结合的可行性,以便在泰国早期检测AD.

主要方法:

  • 在泰国从INDE队列中招募早期痴呆症患者 (CDR ≤1).
  • 使用经过验证的血p-tau217切断值 (>7.46 pg/mL) 确定AD病理.
  • 应用接收器操作特征 (ROC) 分析和尤登指数来确定认知评估的最佳截止分数.

主要成果:

  • 与非AD患者相比,AD患者在MoCA-泰国,MoCA-MIS和MMSE-泰国的得分明显较低.
  • 摩卡-MIS表现出最高的区分能力 (AUROC = 0.762),其次是摩卡-泰国 (AUROC = 0.738) 和MMSE-泰国 (AUROC = 0.725).
  • 对MoCA-Thai (灵敏度=75%,特异性=69%) 确定最佳切线分数为≤21,对于MoCA-MIS (灵敏度=67%,特异性=77%) 确定为≤6.

结论:

  • 一个MoCA-泰国切线≤21和一个MoCA-MIS切线≤6有效地识别研究队列中的AD病理.
  • 这些发现支持将认知查测试与血生物标志物的整合,以提高早期AD检测.
  • 这项研究强调了这些结合方法在泰国临床环境中的潜力,特别是在先进诊断访问有限的地方.