临床表现 临床表现
Yuthachai Sarutikriangkri1,2, Thanakit Pongpitakmetha1,3,4,5, Akarin Hiransuthikul1,6
1Memory Clinic, King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
血p-tau217对阿尔茨海默氏症 (AD) 诊断具有前景. 蒙特利尔认知评估 - 泰国版 (MoCA-泰国) 和MoCA-记忆指数得分 (MoCA-MIS) 的新截止分数有助于在泰国检测AD病理.
科学领域:
- 神经学 神经学
- 生物标志物 生物标志物
- 认知评估 认知评估
背景情况:
- 血p-tau217是一种新兴的阿尔茨海默病 (AD) 生物标志物,提供了更容易获得的诊断替代品.
- 像MoCA-Thai和MMSE-Thai这样的认知查工具在临床环境中至关重要,但它们用于识别AD病理的最佳截止分数,特别是与血生物标志物,在LMIC中不清楚.
- 这项研究调查了MoCA-Thai,MoCA-MIS和MMSE-Thai与血p-tau217一起用于AD诊断的实用性.
研究的目的:
- 评估MoCA-泰国,MoCA-MIS和MMSE-泰国用于阿尔茨海默病 (AD) 的诊断性能,使用血p-tau217.
- 为了确定这些认知测试的最佳切断分数,以确定AD病理.
- 评估将认知查与血生物标志物相结合的可行性,以便在泰国早期检测AD.
主要方法:
- 在泰国从INDE队列中招募早期痴呆症患者 (CDR ≤1).
- 使用经过验证的血p-tau217切断值 (>7.46 pg/mL) 确定AD病理.
- 应用接收器操作特征 (ROC) 分析和尤登指数来确定认知评估的最佳截止分数.
主要成果:
- 与非AD患者相比,AD患者在MoCA-泰国,MoCA-MIS和MMSE-泰国的得分明显较低.
- 摩卡-MIS表现出最高的区分能力 (AUROC = 0.762),其次是摩卡-泰国 (AUROC = 0.738) 和MMSE-泰国 (AUROC = 0.725).
- 对MoCA-Thai (灵敏度=75%,特异性=69%) 确定最佳切线分数为≤21,对于MoCA-MIS (灵敏度=67%,特异性=77%) 确定为≤6.
结论:
- 一个MoCA-泰国切线≤21和一个MoCA-MIS切线≤6有效地识别研究队列中的AD病理.
- 这些发现支持将认知查测试与血生物标志物的整合,以提高早期AD检测.
- 这项研究强调了这些结合方法在泰国临床环境中的潜力,特别是在先进诊断访问有限的地方.
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