生物标志物 生物标志物
Marufjon Salokhiddinov1, Dileep Kumar2, Dharmesh Singh2
1Tashkent Medical Academy, Tashkent, Tashkent, Uzbekistan.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
自动化MRI分析显示,在早期阿尔茨海默病 (AD) 中,左侧叶 (MTL) 和侧叶 (LTL) 的体积损失显著. 这些发现突显了先进的成像技术在早期阿尔茨海默病诊断和监测疾病进展方面的潜力.
科学领域:
- 神经成像是一种神经成像.
- 放射学 放射学是一门学科.
- 医学诊断 医学诊断 医学诊断
背景情况:
- 阿尔茨海默病 (AD) 诊断依赖于识别神经退行变化.
- 早期发现AD对于及时干预和管理至关重要.
- 叶缩是AD进展的一个关键指标.
研究的目的:
- 评估用于早期AD诊断的自动体积测量技术.
- 评估中叶 (MTL) 和侧叶 (LTL) 体积变化的意义在轻度AD.
- 为了研究自动化MRI分析用于AD检测的实用性.
主要方法:
- 使用了39名健康对照组 (HC) 和39名轻度AD患者 (ADNI第3期) 的3T MPRAGEMRI扫描.
- 采用级弱监督的信任集成网络 (CINet) 进行自动体积量化量化.
- 专注于分析MTL和LTL区域的缩,包括分区.
主要成果:
- 与HC患者相比,AD患者的左侧LTL体积 (∼13%) 显著减少 (p <0.05).
- 与HC患者相比,AD患者的右侧LTL体积 (∼10.50%) 显著减少 (p <0.05).
- 在阿尔茨海默病患者中,LTL的体积损失在两性之间一致.
结论:
- 在左MTL和LTL区域观察到较大的体积损失,表明轻度AD中的不对称缩.
- 自动体积测量技术对于阿尔茨海默病的诊断和监测具有重要意义.
- 该研究为早期AD干预策略提供了有价值的见解.
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