生物标志物 生物标志物
Bery Mohammediyan1,2, Sylvia Villeneuve3,4,5, Béatriz Oliveira6,7
1Center for advanced research in sleep medicine, Research Center of the CIUSSS-NIM, Montreal, QC, Canada.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
令人惊的是,阿尔茨海默病风险较高的老年人失眠症状与更好的记忆力和注意力有关. 这表明睡眠障碍可能并不总是对这一群体的认知产生负面影响.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 睡眠医学 睡眠医学
背景情况:
- 研究了阿尔茨海默病 (AD) 风险较高的老年人失眠和认知变化之间的关系.
- 专注于因家族病史而面临高风险的队列.
研究的目的:
- 为了确定失眠是否与高风险人群的认知变化随着时间的推移有关.
- 基于自我报告和客观测量的失眠症状来比较认知表现.
主要方法:
- 研究了348名没有痴呆症的老年人,使用匹兹堡睡眠质量指数 (PSQI) 评估自我报告的失眠.
- 客观睡眠是通过在子样本中通过7天的动图测量.
- 每年评估认知能力,平均为7.15年,包括记忆和注意力测量 (RBANS).
主要成果:
- 较高的自我报告的失眠症状与更好的基线即时和延迟记忆相关.
- 通过动图的客观失眠测量显示了较高的纵向延迟记忆得分.
- 只有客观测量失眠的个体具有最高的纵向延迟记忆得分.
结论:
- 与直觉相反,增加的失眠症状 (自我报告和客观) 与AD风险较高的个体的更好的认知功能有关.
- 这种关联可能表明潜在的保护性生活方式因素可以增强认知能力,但会扰乱睡眠.
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