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Updated: Jan 7, 2026

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粘合剂的线索:从偶然到自然的蓝图,在降解剂的发现中

Zuzanna Kozicka1,2,3

  • 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, U.S.A.

Essays in biochemistry
|December 26, 2025
PubMed
概括

分子降解剂 (MGDs) 重新编程蛋白质相互作用以进行向降解. 本综述概述了系统的发现策略,超越了偶然性,为MGDs制定了合理的设计方法.

关键词:
药物的发现和设计.医学化学 医学化学分子降解剂 分子降解剂有针对性的蛋白质降解降解.无处不在的素连接酶.

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