生物标志物 生物标志物
Smriti Ghildiyal1, Ashwati Vipin2, Gurveen Kaur Sandhu1
1Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
较高的血管风险因素会增加认知能力下降. 对于患有Apolipoprotein E4 (ApoE4) 的人来说,高血压的管理对于预防认知障碍至关重要,特别是在中年.
科学领域:
- 神经学 神经学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 认知能力下降受到年龄,教育和血管风险因素的影响,如高血压 (HTN),高脂血症 (HLD) 和糖尿病 (DM).
- 阿波利波蛋白E4 (ApoE4) 是晚发性阿尔茨海默病的一个重要遗传风险因素.
- 在认知障碍中,血管健康和遗传倾向 (ApoE4) 之间的相互作用需要进一步研究.
研究的目的:
- 检查血管风险因素负担与非痴呆症队列中的认知功能之间的关联.
- 研究个体血管风险因素和ApoE4状态对认知衰退的影响.
- 探索血管风险因素和ApoE4对不同年龄组认知障碍的相互作用影响.
主要方法:
- 从BIOCIS队列中评估了838名非痴呆症参与者.
- 参与者按血管风险负担 (无,一,多) 和年龄组 (中年,晚年) 分层.
- 用全球测试 (MoCA,VCAT) 和神经心理评估 (情节性记忆,执行功能,处理速度,视觉空间功能,语义流) 评估认知功能. 确定了血管风险因素和ApoE4状态.
主要成果:
- 血管风险负担增加与年龄较大,教育程度较低以及所有领域的认知表现较差相关.
- 超脂血症 (HLD) 和糖尿病 (DM) 显著增加了晚年轻度认知障碍 (MCI) 的几率.
- 在中年,高血压 (HTN) 和ApoE4之间的相互作用显著增加了主观认知衰退 (SCD) 和MCI的风险.
结论:
- 较高的血管风险因素数量与认知障碍的风险增加有关.
- 虽然单独HTN并没有直接影响认知分类,但其与ApoE4的结合大大增加了中年认知障碍的风险.
- 建议对ApoE4载体进行高血压的积极管理,以减轻认知能力下降的进展.
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