临床表现 临床表现
Mohammed Adnan Azam1, Ashwati Vipin2, Yi Jin Leow3
1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore, Singapore.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
这项研究开发了数字游戏,以检测轻度认知障碍 (MCI) 并区分其亚型,包括血管,阿尔茨海默氏症和混合. ReCOGnAIze应用程序在识别这些疾病方面显示出高准确度,有助于临床诊断.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 人工智能在医学中的应用
背景情况:
- 血管认知障碍 (VCI) 是导致痴呆的主要原因,通常与阿尔茨海默氏症 (AD) 病理学同时发生.
- 精确区分MCI亚型 (血管,AD,混合) 对于有效的诊断和治疗至关重要.
- 现有的诊断方法可能很复杂,突出了需要可访问的查工具.
研究的目的:
- 开发和验证能够检测轻度认知障碍 (MCI) 的数字游戏.
- 要区分MCI的亚型,特别是血管,阿尔茨海默氏症和混合类型.
- 利用机器学习来根据认知游戏表现对MCI病理进行分类.
主要方法:
- 分析了389名受试者的神经心理和认知数据 (认知正常和MCI).
- 通过FLAIR成像测定白质超强度 (WMH) 负载的量化和通过血氨基酸β 42/40比率测定粉样蛋白水平.
- 开发4个数字游戏来评估认知领域和机器学习模型,以根据游戏特征区分MCI亚型.
主要成果:
- 综合游戏得分准确地检测了MCI从认知正常 (AUC=0.89) 和分化血管从非血管MCI (AUC=0.88).
- 该系统在区分混合MCI (AUC=0.9) 和阿尔茨海默氏症MCI (AUC=0.9) 在各自组内实现了高精度.
- 对230名新受试者的验证证实了数字游戏在检测和分类MCI亚型方面的有效性.
结论:
- 该ReCOGnAIze应用程序显示了早期检测MCI的巨大潜力.
- 该工具有效地区分了血管,阿尔茨海默氏症和混合MCI亚型.
- 这些发现支持使用ReCOGnAIze应用程序来指导临床决策和进一步的诊断评估.
相关概念视频
Chronic Kidney Disease II: Clinical Manifestations
520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations
299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis
364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations
436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management
652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies
437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437


