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在毒症患者中使用IV维生素C的趋势
Romy E Segall1, François Lamontagne2, Emily A Vail3
1Department of Medicine, University of Toronto, Toronto, ON, Canada.
Critical care medicine
|December 26, 2025
概括
对于败血症患者来说,静脉注射维生素C的使用并不常见,在2016年的研究后增加,但随着试验数据的出现,在COVID-19大流行期间下降. 这一趋势突出显示了对败血症管理的治疗观念的不断变化.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 静脉注射 (IV) 维生素C已被探索为治疗败血症.
- 关于其有效性的证据已经演变,影响了临床实践.
- 了解IV维生素C治疗败血症的趋势至关重要.
研究的目的:
- 分析美国住院败血症患者IV维生素C使用趋势.
- 检查如何演变的证据,包括一个关键的前后研究和随后的试验,影响了IV维生素C的管理.
- 评估从2008年到2021年的IV维生素C利用模式.
主要方法:
- 使用Premier医疗保健数据库 (2008-2021) 进行回顾性队列研究.
- 包括超过1100万成年住院患者,在1115家美国医院诊断出败血症.
- 与研究期和临床事件相比,IV维生素C的时间和频率的分析.
主要成果:
- 总体而言,IV维生素C的使用并不频繁 (0.3%的败血症患者).
- 管理最初下降,在2016年研究后上升,在2020年初达到顶峰,然后下降.
- 趋势在不同患者严重性亚队伍中一致,并显示出医院一级的显著变化.
结论:
- 美国医院对败血症的IV维生素C处方仍然不常见.
- 使用模式反映了对新兴研究的反应,包括2016年后显著增加的研究.
- 随着COVID-19的流行,出现了下降,这可能是由于新出现的临床试验数据.
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