生物标志物 生物标志物
Vorapun Senanarong1,2, Tanyaluck Thientunyakit3, Chatchawan Rattanabannakit2
1Division of Neurology, Department of Medicine, Faculty of Medicine, Siriraj hospital, Mahidol university, Bangkok, Thailand.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
这项研究确定了在泰国诊断阿尔茨海默病 (AD) 的血生物标志物的最佳切断值. 血p-tau217在区分AD与非AD群体方面表现出最高的准确性.
科学领域:
- 神经学 神经学
- 生物标志物发现发现
- 痴呆症的诊断 痴呆症的诊断
背景情况:
- 阿尔茨海默病 (AD) 诊断依赖于侵入性方法.
- 基于等离子体的生物标志物为AD检测提供了一个不那么侵入性的替代方案.
- 确定局部截止值对于特定人口的准确性至关重要.
研究的目的:
- 确定阿尔茨海默病 (AD) 血生物标志物的局部切断值.
- 评估血生物标志物的诊断性能,以区分泰国人口中的AD和非AD亚组.
- 为了验证血生物标记物与粉样蛋白PET和CSF标记物相比.
主要方法:
- 涉及97名参与者的前性研究 (AD,非AD痴呆症,MCI/对照).
- 分析了Aβ-PET (18F-florbetapir) 和等离子体生物标志物 (Aβ40,Aβ42,p-tau181,pTau217,GFAP) 的情况.
- 使用接收器操作特征 (ROC) 分析来确定切断值.
主要成果:
- 血p-tau217在区分AD阳性和AD阴性组中显示了最高的准确性 (87.14%).
- 血GFAP (77.89%),pTau181 (73.20%) 和Aβ42/40比率 (72.63%) 也显示出显著的诊断性能.
- 所有测试的血生物标志物都显示出有前途的诊断能力.
结论:
- 血生物标志物在痴呆症诊断中具有显著的临床使用潜力.
- 血p-tau217是区分AD最有效的生物标志物.
- 这些发现支持使用血生物标志物在泰国人口中诊断AD.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
746
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
746
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
511
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
511