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临床表现 临床表现

Cay Anderson-Hanley1,2, Nelson A Roque3, Josh Rogers2

  • 1Neuroscience Program, Union College, Schenectady, NY, USA.

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概括
此摘要是机器生成的。

一个新的电子Stroop任务 (eStroop C) 与纸张Stroop (pStroop C) 显示了适度的相关性,为执行功能提供了可比的数字生物标志物. 这种自给药工具适用于评估轻度认知障碍 (MCI) 的远程临床试验.

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科学领域:

  • 神经科学是一个神经科学.
  • 数字健康数字健康
  • 临床试验 临床试验

背景情况:

  • 数字生物标志物对于评估轻度认知障碍 (MCI) 和阿尔茨海默病及相关痴呆症 (ADRDs) 的认知功能至关重要.
  • 评估数字工具与传统神经心理评估的可比性对于远程临床试验设计至关重要.
  • 在临床研究中,COVID-19大流行加速了对远程,数字评估方法的需求.

研究的目的:

  • 为了比较一个新的电子Stroop任务 (eStroop C) 与传统的纸张Stroop任务 (pStroop C) 的性能.
  • 评估eStroop C作为MCI患者执行功能的数字生物标志物.
  • 评估在远程临床试验环境中使用自行管理的数字Stroop任务的可行性.

主要方法:

  • 一个新的电子Stroop任务 (eStroop C) 和一个传统的纸张Stroop任务 (pStroop C) 通过视频会议远程向MCI患者和护理人员 (n=95) 进行.
  • 这两个任务都评估了执行功能,特别关注干扰性能.
  • 参与者使用研究发布的安卓平板电脑进行eStroop C,而pStroop C则使用纸张刺激进行.

主要成果:

  • 在eStroop C和pStroop C的干扰部分显示了中等的相关性 (r=0.59,p<0.001).
  • 这表明,数字测量捕捉了执行职能与传统的纸质测试相似的方面.
  • 结果支持使用eStroop C作为一个可行的数字替代品.

结论:

  • 电子Stroop任务 (eStroop C) 提供了与传统的纸张Stroop (pStroop C) 相当的执行功能的测量.
  • eStroop C是一个适合于MCI临床试验中远程神经心理评估的数字生物标志物.
  • 这种自主管理的数字Stroop任务为未来的研究提供了高效和定期评估的潜力.