生物标志物 生物标志物
1University of Maryland of Baltimore, Baltimore, MD, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
在全球范围内,较高的大脑 (BEN) 表明阿尔茨海默病 (AD) 风险增加. 然而,特定大脑区域的局部BEN增加可能表明认知性和AD风险降低,突出显示AD的双重作用.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 认知科学 认知科学
背景情况:
- 大脑 (BEN) 使用样本 (Sample Entropy) 等方法量化大脑信号不规则性.
- 关于阿尔茨海默病 (AD) 中纵向BEN变化的研究有限.
- 这项研究使用静止状态fMRI (rsfMRI) 研究特定大脑区域的纵向BEN变化.
研究的目的:
- 为了检查在八个兴趣的大脑区域 (ROI) 的样本透度的纵向变化.
- 评估BEN,认知功能 (MMSE),教育和艾滋病风险队列中的性别之间的关联.
- 探索BEN在AD进展中的双重作用和潜在的认知性.
主要方法:
- 分析了PREVENT-AD数据集中的122名参与者的rsfMRI数据.
- 使用fMRIPrep进行rsfMRI数据预处理,包括运动校正和正常化.
- 计算8个ROI的样本和使用R.中的线性混合模型进行统计分析.
主要成果:
- 年龄,全脑BEN,左额叶上皮层的BEN,左和右海马,以及性别与认知得分有显著的关联.
- 增加全脑BEN与较高的认知衰退相关.
- 在左额头上皮层和海马体中BEN的升高与认知衰退的减少有关,这表明它具有保护作用.
结论:
- 全脑BEN升高可能表明AD风险增加和神经病理变化.
- 特定区域的BEN增加,特别是在额叶皮层和海马,可能反映了神经适应能力和认知性.
- BEN在AD中表现出双重作用,全球增加表明进展,区域增加可能表明保护机制.
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