Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer's disease.

PloS one·2018
Same author

Amyloid-β - a reflection of risk or a preclinical marker?

Nature reviews. Neurology·2018
Same author

Prevalence and Outcomes of Amyloid Positivity Among Persons Without Dementia in a Longitudinal, Population-Based Setting.

JAMA neurology·2018
Same author

The association of mid-to late-life systemic inflammation with white matter structure in older adults: The Atherosclerosis Risk in Communities Study.

Neurobiology of aging·2018
Same author

White Matter Reference Region in PET Studies of <sup>11</sup>C-Pittsburgh Compound B Uptake: Effects of Age and Amyloid-β Deposition.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2018
Same author

Brain structure and cognition 3 years after the end of an early menopausal hormone therapy trial.

Neurology·2018
Same journal

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

生物标志物 生物标志物

Robel K Gebre1, Scott A Przybelski1, Sheelakumari Raghavan1

  • 1Mayo Clinic, Rochester, MN, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
概括
此摘要是机器生成的。

一个新的机器学习分数,THETA,通过检测降低病理,有效地识别阿尔茨海默病的认知性. 这一分数有助于理解性机制和跟踪疾病进展.

更多相关视频

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

相关实验视频

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

科学领域:

  • 神经科学是一个神经科学.
  • 生物标志物 生物标志物
  • 机器学习 机器学习

背景情况:

  • 区分认知性与典型的阿尔茨海默病 (AD) 病理是具有挑战性的,因为重叠的生物标志物概况.
  • 对AD病理学的认知性是理解疾病机制的关键研究领域.
  • 机器学习 (ML) 方法为AD的新生物标志物开发提供了潜力.

研究的目的:

  • 评估tau异质性得分 (THETA) 作为对阿尔茨海默病认知弹性的有效标记.
  • 与现有的生物标志物相比,评估THETA能够更好地估计的时间进展的能力.
  • 根据tau的分布和进展来区分典型的AD,弹性和抗性群体.

主要方法:

  • 分析了来自梅奥诊所衰老研究 (MCSA) 和ADRC的纵向成像数据.
  • 参与者被分为典型的AD,弹性和耐药组,使用粉样蛋白PiB-PET,Flortaucipir (FTP-PET) 和MMSE.
  • 使用ML模型生成区域THETA分数以捕捉空间tau异质性;使用SILA与等离子体生物标志物 (p-tau181,GFAP) 建模进展.

主要成果:

  • 与典型的AD组相比,THETA在性个体中确定了减少tau吸收和保留皮质厚度的区域.
  • 采样代局部近似 (SILA) 模型展示了THETA在不同群体中区分全球时间进展的能力.
  • 在弹性和典型的AD群体中观察到GFAP (炎症标志物) 的早期发病,这表明早期的炎症过程.

结论:

  • 在性个体中,THETA有效地识别了降低的tau病理和保存的皮质厚度,使其与典型的AD区分开来.
  • 在揭示病理性机制的基础上,THETA显示了潜在的潜力,提高了对AD的理解.
  • 这些发现表明,THETA可以提供有关弹性机制的宝贵见解,并改善AD进展建模.