怀孕中的孕产妇肥胖:子女神经发育结果的危险因素
Luisa O Schmitt1,2, Giuseppe Faraco1, Tamires S Stivanin1,2
1Laboratory of Neuroimmune-Metabolism, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
Journal of neurochemistry
|December 26, 2025
概括
孕产妇的肥胖严重影响后代的神经发育,增加代谢和精神疾病的风险. 本综述探讨了产前脂肪积累如何影响胎儿大脑发育和长期健康结果.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 公共卫生 公共卫生
背景情况:
- 肥胖是一种全球性流行病,其特点是过度的脂肪积累和能量失衡.
- 孕产妇肥胖率正在上升,对母亲和孩子构成重大风险.
- 怀孕期间母亲的肥胖会导致后代的急性和慢性健康问题,包括代谢,荷尔蒙,神经发育和精神疾病.
研究的目的:
- 审查母亲肥胖对后代神经发育的影响.
- 探索母亲肥胖影响胎儿大脑发育的机制.
- 了解母亲肥胖和后代行为障碍之间的联系.
主要方法:
- 文献综述专注于研究研究母亲肥胖和后代神经发育.
- 在孕产妇肥胖的背景下,对健康和疾病的发育起源 (DOHaD) 理论的研究分析.
- 综合了关于母亲肥胖对胎儿大脑结构,功能和神经炎症的影响的研究结果.
主要成果:
- 孕产妇的肥胖可以重新编程胎儿的免疫,代谢,内分泌和神经系统.
- 产前暴露于母亲肥胖会影响后代的新陈代谢和心理健康.
- 具体影响包括大脑神经发育,神经回路,突触,质细胞和神经炎症的改变,导致行为障碍.
结论:
- 孕产妇的肥胖是影响后代神经发育和长期健康的关键因素.
- DOHaD理论为理解这些效应提供了一个框架.
- 需要进一步的研究来缓解孕产妇肥胖对神经发育的不利影响.
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