痴呆症护理研究和心理社会因素
Carlos Tyler Roncero1, Anthony E Lang2, Durjoy Lahiri3
1Baycrest Academy for Research and Education, Toronto, ON, Canada.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
跨直流刺激 (tDCS) 改善了神经退行性疾病患者的步行速度和节奏,如渐进性上核麻 (PSP) 和皮层骨干退行 (CBD). 这些移动性改善在干预后两周持续.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 康复 康复 康复 康复
背景情况:
- 渐进性超核性麻 (PSP) 和皮层细胞底性退化 (CBD) 是神经退行性疾病,治疗选择有限.
- 通过增加皮层刺激性来增强运动功能的潜力,正在探索跨直流刺激 (tDCS).
研究的目的:
- 研究针对运动皮质和中脑的tDCS在改善PSP和CBD患者的行走能力方面的有效性.
- 评估在tDCS治疗后立即和持续的步态改善.
主要方法:
- 10名参与者 (9名PSP患者) 接受了3周的12次行走,包括一个SHAM (安慰剂) 周和一个活跃的tDCS周.
- tDCS涉及运动皮层 (Cz) 上的阳极和右肌肌肉上的阴极.
- 步行参数 (速度,节奏,稳定性) 在干预前和后被评估,包括两周的随访.
主要成果:
- 刺激后两周,观察到节奏 (步数/分钟) 和速度 (厘米/秒) 的显著改善.
- 与基线相比,节奏增加了大约14%,速度增加了大约25%.
- 虽然立场百分比有所改善,但没有达到统计学意义.
结论:
- tDCS显示出作为一种安全和可行的神经调节方法来增强PSP和CBD患者的移动性的潜力.
- 观察到的持续的步态改善需要进一步研究tDCS来管理这些神经退行性疾病的症状.
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