生物标志物 生物标志物
Sevil Yasar1, Andrea Anderson2, Kathleen M Hayden3
1Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
这项研究发现,血管酶转化酶2 (ACE-2) 的活性随着时间的推移在患有2型糖尿病的成年人中增加. 在认知障碍的参与者和非白人个体中观察到某些宁-血管酶系统酶的水平较低.
科学领域:
- 生物化学 生物化学
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
背景情况:
- 氨酸- ангиотензин系统 (RAS) 与阿尔茨海默病 (AD) 的发展有关.
- 在阿尔茨海默病中RAS成分的前性研究是有限的.
- 这项研究调查了血ACE-1,ACE-2,血管新生素II (ANG-II) 和血管新生素1-7 (ANG1-7) 随着时间的推移,认知状态和种族的变化.
研究的目的:
- 为了确定血ACE-1,ACE-2,ANG-II和ANG1-7.1的纵向变化.
- 根据认知状态来评估这些标记物的差异.
- 为了检查RAS酶水平的种族差异.
主要方法:
- 对Look AHEAD研究 (n=310) 的二次分析,随访时间为12年.
- 参与者是没有痴呆症的成年人,体重过重/肥胖和T2DM,不包括RAS药物使用者.
- 血ACE和血管素水平通过ELISA和活性测定测量;认知状态判断;按种族分层.
主要成果:
- 从第1年到第10年,ACE-2活性显著增加.
- 从第一年到第四年,ANG1-7水平显著增加.
- 认知障碍参与者的ANG1-7水平较低;与白人参与者相比,非白人参与者的ANGII水平较低.
结论:
- 在T2DM的老年人中,ACE-2酶活性在纵向上升.
- 某些RAS酶的较低水平与认知障碍和非白人种族有关.
- 这些发现表明ACE-2在认知功能中的潜在作用,并突出了RAS标志物的种族差异.
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