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相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

746
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
746
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

511
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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相关实验视频

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

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生物标志物 生物标志物

Sevil Yasar1, Andrea Anderson2, Kathleen M Hayden3

  • 1Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
概括
此摘要是机器生成的。

这项研究发现,血管酶转化酶2 (ACE-2) 的活性随着时间的推移在患有2型糖尿病的成年人中增加. 在认知障碍的参与者和非白人个体中观察到某些宁-血管酶系统酶的水平较低.

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Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
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相关实验视频

Last Updated: Jan 7, 2026

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科学领域:

  • 生物化学 生物化学
  • 神经科学是一个神经科学.
  • 内分泌学 在内分泌学.

背景情况:

  • 氨酸- ангиотензин系统 (RAS) 与阿尔茨海默病 (AD) 的发展有关.
  • 在阿尔茨海默病中RAS成分的前性研究是有限的.
  • 这项研究调查了血ACE-1,ACE-2,血管新生素II (ANG-II) 和血管新生素1-7 (ANG1-7) 随着时间的推移,认知状态和种族的变化.

研究的目的:

  • 为了确定血ACE-1,ACE-2,ANG-II和ANG1-7.1的纵向变化.
  • 根据认知状态来评估这些标记物的差异.
  • 为了检查RAS酶水平的种族差异.

主要方法:

  • 对Look AHEAD研究 (n=310) 的二次分析,随访时间为12年.
  • 参与者是没有痴呆症的成年人,体重过重/肥胖和T2DM,不包括RAS药物使用者.
  • 血ACE和血管素水平通过ELISA和活性测定测量;认知状态判断;按种族分层.

主要成果:

  • 从第1年到第10年,ACE-2活性显著增加.
  • 从第一年到第四年,ANG1-7水平显著增加.
  • 认知障碍参与者的ANG1-7水平较低;与白人参与者相比,非白人参与者的ANGII水平较低.

结论:

  • 在T2DM的老年人中,ACE-2酶活性在纵向上升.
  • 某些RAS酶的较低水平与认知障碍和非白人种族有关.
  • 这些发现表明ACE-2在认知功能中的潜在作用,并突出了RAS标志物的种族差异.