由金属纳米颗粒诱导的产性机制范式 - - 一个小小的综述
Meenu Singh1, Yeshvandra Verma1, Suresh Vir Singh Rana2
1Department of Toxicology, Chaudhary Charan Singh University, Meerut, 250 004, India.
概括
金属纳米粒子 (NP) 构成健康风险,通过氧化应激,炎症和亡引起母胎毒性. 了解这些机制对于风险评估和开发更安全的纳米材料至关重要.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 纳米技术纳米技术
背景情况:
- 纳米粒子 (NP) 的生产和使用正在迅速增加,引发了人们对潜在的健康和环境风险的担忧.
- 独特的NP特性使细胞进入和生物积累,与生物系统相互作用.
- 这些相互作用可以通过氧化应激,炎症,亡和DNA损伤等机制导致毒性.
研究的目的:
- 审查纳米粒子诱导的致性背后的机制,特别是来自金属NP.
- 突出氧化应激,炎症,亡和自在母胎毒性中的作用.
- 强调需要基于机制的选,以实现更安全的纳米材料设计.
主要方法:
- 文献综述侧重于NP毒性机制.
- 分析了将NP暴露与产性相关的数据.
- 检查参与NP诱导胎儿毒性的细胞通路.
主要成果:
- 氧化应激和反应性氧物种 (ROS) 生成是NP诱导的母胎毒性的主要驱动因素.
- NP会引发胎儿炎症,结构异常,细胞亡和DNA损伤,导致细胞毒性.
- 自在怀孕期间在NP暴露后的细胞死亡中起着重要作用,影响生殖过程.
结论:
- 了解NP产性对于健康风险评估和开发更安全的纳米材料至关重要.
- 基于机制的,高通量体外查可以预测NP诱导的产性.
- 对NP诱导的毒性机制的进一步研究将指导更安全的纳米材料的设计.
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