对支持 STOPP/START.version 3 标准的参考文献进行评估
B Boland1,2, F X Sibille3,4,5, A Mouzon6
1Geriatric Medicine, Cliniques Universitaires Saint-Luc, Brussels, Belgium. Benoit.Boland@uclouvain.be.
European geriatric medicine
|December 26, 2025
概括
评估了支持STOPP/START版本3 (SS.v3) 标准的证据. 大多数START标准有强有力的证据,但由于有限的高级别证据,不到一半的STOPP标准需要重新评估.
科学领域:
- 老年人药理学 老年人药理学
- 基于证据的医学 基于证据的医学
- 临床标准开发 临床标准开发
背景情况:
- STOPP/START版本3 (SS.v3) 标准的证据基础存在争议,可能会阻碍临床采用.
- 本研究批判性地评估了支持SS.v3标准的参考文献.
研究的目的:
- 评估190个SS.v3标准所引用的参考文献的质量和适当性.
- 确定支持每个SS.v3标准的证据水平.
主要方法:
- 190个SS.v3标准的所有454个参考被老年病专家审查.
- 根据研究设计 (RCT,队列,病例控制等) 将证据水平分类 (I-V). ) 的情况.
- 如果引用不匹配,缺乏支持或在临床上不一致,则被认为不合适.
主要成果:
- 参考文献中很大一部分 (322/454) 是审查 (70% STOPP,71% START).
- 高级证据 (I级) 支持43%的STOPP标准和88%的START标准.
- 10个标准 (8%的STOPP) 缺乏适当的支持参考.
结论:
- 大多数START标准都得到了强有力的证据支持,与许多STOPP标准不同.
- 需要重新评估STOPP标准及其支持文献.
- 临床医生必须在与老年患者共享决策时考虑证据限制.
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