生物标志物 生物标志物
Dvir Dori1, Maliha Chowdhury2,3, Nicole D Anderson4,5
1Rotman Research Institute-Baycrest, TORONTO, ON, Canada.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
按瘦身量 (Grip/LBM) 规范化的握力是老年人认知表现的强有力的预测指标. 这种神经肌肉测量可以作为大脑神经元完整性和认知健康的实际生物标志物.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 生物标志物 生物标志物
背景情况:
- 老化中的认知衰退并不能完全由已知的病理学,如粉样蛋白或粉样蛋白解释.
- 神经元和突触健康是认知功能的关键因素.
- 最大握力反映了运动单元的健康状况,包括神经结构.
研究的目的:
- 调查老年人肌肉质量 (Grip/LBM) 规范化的握力与认知表现之间的关系.
- 为了确定握力/LBM是否比单独的握力或瘦身质量更好地预测认知.
- 探索Grip/LBM作为大脑神经元完整性的潜在替代标记物.
主要方法:
- 评估了232名具有主观或轻度认知障碍的老年人 (50-95岁).
- 使用动力计测量握力和通过DXA通过瘦身质量.
- 使用蒙特利尔认知评估 (MoCA) 评估认知表现,并使用相关性和回归分析关联.
主要成果:
- 握力/腰椎瘤与MoCA得分有显著的正相关性 (r=0.286,p < 0.00001).
- 感冒/肌瘤是MoCA得分的显著预测因素 (β=4.69,p=0.001),解释了与年龄和性别相关的22.4%的差异.
- 仅仅抓握力和瘦身量是较弱的预测因素;这种关联在男性中更强.
结论:
- 握力/LBM是认知健康的强有力的预测指标,其表现优于握力或瘦身质量的个体测量.
- 通过Grip/LBM表示的神经肌肉功能,可以作为大脑神经元完整性的替代标记.
- Grip/LBM具有作为认知健康的实用生物标志物和干预的目标的潜力.
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