生物标志物 生物标志物
1Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
脑血管疾病 (CeVD) 生物标志物,包括扩散MRI测量,比白质超强度 (WMH) 早10年表现出进展. 这一发现有助于早期检测和干预血管对认知障碍 (VCI) 的贡献.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 生物标志物发现发现
背景情况:
- 脑血管疾病 (CeVD) 是阿尔茨海默氏症的关键共同病理,影响认知障碍 (VCI) 估计.
- 目前CeVD的操作性有限,这阻碍了对血管对认知障碍的贡献的准确评估.
- 新的扩散MRI标记物 (FA,FW,PSMD,ARTS) 和WMH被提出作为CeVD早期和晚期变化的替代物.
研究的目的:
- 描述CeVD生物标志物的时间进展,包括扩散MRI标志物和WMH.
- 建立可靠的切割点来分类正常与异常CeVD生物标志物状态.
- 加强CeVD生物标志物分期,以提高临床效用.
主要方法:
- 利用3,953名梅奥诊所老龄化参与者研究中的CeVD生物标志物数据进行分类和切割点估计.
- 采用非线性混合效应 (NLME) 模型来分析来自2047名参与者的纵向数据,检查时间进展.
- 将年龄,性别,血管风险,教育和APOE4状态等共变量纳入时间进展模型.
主要成果:
- 扩散MRI生物标志物始终在比白质超强度 (WMH) 早大约10年表现出进展.
- 全脑扩散MRI测量 (FW,PSMD,ARTS) 与WMH有很高的相关性,表明与时间偏移的同步进展.
- 区域真实指标在几十年内表现出更早,更稳定的进展,与WMH的相关性较低.
结论:
- 使用VCI分类的扩散MRI标记器的确定的切点,准确度年轻的参考标准显示出卓越的性能.
- 与WMH相比,扩散MRI标记表明CeVD进展较早,这强调了它们的早期检测潜力.
- 这些发现支持扩散MRI标记物的使用,以改善CeVD和VCI的临床评估和有针对性的干预措施.
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