生物标志物 生物标志物
Hye Won Chai1, Abigail Stephan1, Christy Phillips1
1Clemson University, Institute for Engaged Aging, Seneca, SC, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
客观的睡眠测量与农村老年人的主观报告保持一致. 匹兹堡睡眠质量指数 (PSQI) 可以作为一个具有成本效益的工具来评估睡眠质量,并帮助预防阿尔茨海默氏症和相关痴呆症 (AD/ADRD).
科学领域:
- 老年学是一门学科.
- 睡眠科学 睡眠科学
- 神经科学是一个神经科学.
背景情况:
- 睡眠障碍与老年人认知能力下降以及阿尔茨海默氏症和相关痴呆症 (AD/ADRD) 风险有关.
- 不同的睡眠指标产生不一致的结果,需要检查不同指标之间的关联.
- 农村的老年人是高风险群体,在睡眠和AD/ADRD研究中代表性不足.
研究的目的:
- 调查农村老年人客观睡眠测量 (睡眠分析仪) 与自我报告的每日睡眠之间的一致性.
- 探索主观,基于调查的匹兹堡睡眠质量指数 (PSQI) 评分和客观睡眠参数之间的关系.
- 了解睡眠在农村老年人群中对ADRD风险和预防的作用.
主要方法:
- 利用了28名参与者的日常功能干预试验 (NCT04651582) 的基线数据.
- 收集了14天的基于智能手机的自我报告睡眠数据,包括睡眠质量,睡眠开始/维持,以及感觉清爽.
- 采用无线脑电图 (EEG) 监视器 (Sleep ProfilerTM) 进行客观的睡眠指标,如REM和NREM的百分比和延迟.
- 管理匹兹堡睡眠质量指数 (PSQI) 来评估各种睡眠质量维度.
主要成果:
- 较高的NREM第3阶段 (深度睡眠) 百分比与更好的日常睡眠质量和更清新的感觉相关.
- 增加的PSQI总得分 (表明睡眠不佳) 与更长的NREM第3阶段延迟时间 (达到深度睡眠的时间) 相联系.
- 客观的NREM睡眠测量结果与主观的每日睡眠报告和PSQI得分达成一致.
结论:
- 客观的NREM睡眠测量在很大程度上与农村老年人的主观睡眠评估 (每日报告和PSQI) 相一致.
- 睡眠质量指标 (PSQI) 显示出其作为一个具有时间和成本效益的睡眠质量评估工具的潜力,可与客观措施相提并论.
- 研究结果支持早期睡眠干预以预防AD/ADRD,特别是在农村人口中,睡眠诊断的获取有限.
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