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Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat
Published on: July 26, 2015
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在美国和欧洲之间比较年龄和性别特定的估计淋巴细胞过率的参考值
Megan E Astley1,2, Alberto Ortiz3,4, Stein Hallan5,6
1Amsterdam UMC location University of Amsterdam, ERA Registry, Medical Informatics, Meibergdreef 9, Amsterdam, The Netherlands.
Clinical journal of the American Society of Nephrology : CJASN
|December 26, 2025
概括
估计的膜过率 (eGFR) 参考值在健康的美国人和欧洲人之间是相似的. 这表明eGFR值可以在不同人群中推广,即使没有病风险因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 在缺乏病风险因素的种群中,估计的球过率 (eGFR) 变异性尚未得到充分理解.
- 确定特定人群的eGFR参考值对于准确的功能评估至关重要.
研究的目的:
- 为健康的美国成年人制定eGFR参考值.
- 将这些值与现有的欧洲eGFR参考值进行比较.
主要方法:
- 这是一项采用9000多名健康美国人 (NHANES) 和150多万欧洲人 (CKD负担联盟) 的数据进行的横截面研究.
- 根据14个标准确定健康状况,不包括并发病,生活方式因素和药物使用.
- 使用欧洲功能联盟 (EKFC) 方程计算的eGFR,并使用通用添加模型根据年龄和性别进行分析.
主要成果:
- 20岁的美国和欧洲男性的EGFR中位数为98mL/min/1.73m2;对于女性来说,它是101mL/min/1.73m2.
- 在40岁时,eGFR开始下降,这与EKFC方程结构一致.
- 到79岁时,男性的EGFR中位数约为67-68毫升/分钟/1.73米2,女性为63-64毫升/分钟/1.73米2.
- 在排除了具有危险因素的个体后,eGFR分布在健康的美国人和欧洲人之间是相似的.
结论:
- 对于健康的美国人来说,开发的eGFR参考值与欧洲人群的eGFR参考值相当.
- 当考虑没有病风险因素的个体时,eGFR参考值似乎可以在不同人群中推广.
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