入院中性粒细胞与淋巴细胞的比率预测了住院老年人的短期和长期死亡率:一项回顾性多中心研究
Luca Antognoli1, Jacopo Sabbatinelli2,3, Mirko Di Rosa4
1Innovative Models for Aging Care and Technology, IRCCS INRCA, Istituto Nazionale di Riposo e Cura per Anziani, Ancona, Italy.
Aging and disease
|December 26, 2025
概括
在入院时高的中性粒细胞与淋巴细胞比率 (NLR) 预测了老年人死亡率. 这种简单的血液测试有助于评估老年患者的短期和长期生存风险.
科学领域:
- 老年医学 老年医学
- 炎症生物标志物 炎症生物标志物
- 预测分析在医疗保健中的应用
背景情况:
- 中性粒细胞与淋巴细胞的比率 (NLR) 是系统性炎症的公认生物标志物.
- 关于NLR在住院老年人的长期预后价值的证据有限.
研究的目的:
- 评估入院NLR对老年患者住院和48个月全因死亡率的预测能力.
- 调查NLR作为老年人短期和长期结果的预后工具.
主要方法:
- 在意大利老年医院 (2020-2024) 的16,099例急性医疗住院中进行了回顾性多中心队列研究.
- 分析了10,826名65岁以上的患者,其中9,812人在出院后的48个月内进行了跟踪.
- 从全血细胞计数计算入院NLR;通过ROC分析确定值;使用生存分析模型评估结果.
主要成果:
- 入院NLR≥5.36显著增加了住院死亡风险 (HR: 2.287).
- 高NLR≥5.05预测48个月死亡率更高 (调整HR: 1.423),高NLR组的死亡率为51.6%,高NLR组的死亡率为26.3%.
- NLR水平与年龄相关,在老年男性中较高;动态的NLR升高在医院死亡之前.
结论:
- 住院NLR是住院老年人短期和长期死亡率的强大,独立的预测指标.
- 简单的NLR测试支持其在老年人群的风险分层中使用.
- 建议进一步验证最佳的NLR截止值.
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