生物标志物 生物标志物
Sophie E Mastenbroek1,2,3, Lyduine E Collij1,2,3, Jacob W Vogel4
1Amsterdam Neuroscience, Brain Imaging, Amsterdam, Netherlands.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
使用嗅觉测试和CSFα-synuclein种子放大试验的新两步工作流可以准确地识别Lewy体病理,减少侵入性测试需求.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物发现发现
- 神经病理学神经病理学
背景情况:
- 脑脊液 (CSF) 种子放大试验 (SAA) 在检测勒维体病理 (LBP) 的α-synuclein (αsyn) 种子方面是有效的.
- 脑液采样是侵入性的,昂贵的,耗时的,阻碍了广泛的临床应用.
- 开发了一种经神经病理验证的两步工作流程,将嗅觉功能和CSF αsyn SAA结合起来,以改善LBP诊断.
研究的目的:
- 开发和评估一个两步工作流程,以准确的死后确定莱维体病理 (LBP) 状态.
- 评估不同临床群体的工作流的表现,包括患有帕金森症,阿尔茨海默病 (AD) 综合征和临床无损的个人.
- 确定需要进行确认性CSF测试的潜在减少.
主要方法:
- 一组358人接受了死前气味测试 (UPSIT),脑脊液αsyn SAA和死后神经病理评估.
- 第1步涉及使用UPSIT分数,年龄和性别预测皮质LBP的风险分层模型.
- 第二步仅对高风险个体进行确认性CSFαsynSAA,对整个队列和特定子组的表现进行评估.
主要成果:
- 在所有评估组中,两步工作流程在识别皮质LBP方面表现出高准确性 (93-95%).
- 它显著减少了CSF测试要求,根据临床亚组,从-23%到-80%不等.
- 积极的预测值在75-96%之间,负的预测值在95-98%之间,在临床帕金森症和临床AD等特定子组的高性能.
结论:
- 整合嗅觉功能和CSF αsyn SAA的两步工作流提供了一种不那么侵入性的,可能更具成本效益的方法来诊断LBP.
- 这种方法可以减少患者和医疗保健系统对腰部刺穿等侵入性手术的负担.
- 工作流的高准确性和效率支持其在各种临床环境中实施,以改善LBP评估.
相关概念视频
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These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Cardiac myocytes produce these hormones in response to ventricular stretching...
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