生物标志物 生物标志物
1Columbia University, New York, NY, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
一个便携式聚焦超声波 (FUS) 系统安全有效地打开了阿尔茨海默病 (AD) 患者的血脑屏障,降低了β-粉样蛋白水平. 实时洞穴映射指导治疗,显示与治疗结果的强烈相关性.
科学领域:
- 神经学 神经学
- 生物医学工程 生物医学工程
- 医疗成像医学成像
背景情况:
- 血脑屏障 (BBB) 限制了神经疾病治疗的有效性.
- 使用微泡的聚焦超声波 (FUS) 可以暂时打开BBB.
- 对于阿尔茨海默病 (AD) 的现有FUS系统通常是MRI-bound或侵入性.
研究的目的:
- 评估一款便携式FUS系统,用于阿兹海默症患者的床边BBB开口.
- 评估FUS介导的BBB打开的安全性和有效性.
- 为治疗指导使用实时化映射.
主要方法:
- 五名阿尔茨海默症患者接受了跨脑FUS,微泡针对前额叶皮层.
- 一个实时化映射系统 (被动声学映射与一致性因子校正) 监测了微泡活动.
- 在AD患者临床应用之前,该系统在非人类灵长类动物中得到了优化.
主要成果:
- 60%的患者表现出降低的β-粉样蛋白水平,由PET成像证实 (SUVr降低).
- 在化剂量和β-粉样蛋白减少之间观察到强烈的相关性 (80%).
- 便携式FUS系统在20-30分钟内证明了安全高效的BBB打开.
结论:
- 一个便携式FUS系统是安全和有效的降低β-粉样在轻度至中度的AD.
- 实时化映射提供了对治疗安全性和有效性的关键反.
- 未来的研究将探索FUS对认知和tau病理学的影响.
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