生物标志物 生物标志物
Linda Zhang1, Jesús Silva-Rodríguez1, Eva Alfayate1
1CIEN Foundation, Reina Sofia Alzheimer Center, ISCIII, Madrid, Madrid, Spain.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
在没有认知障碍的个体中,血p-tau217水平升高与阿尔茨海默病 (AD) 相关区域的皮质平均扩散率 (MD) 增加有关. 这些发现表明,在认知能力下降之前可以检测到早期的微观结构变化.
科学领域:
- 神经成像是一种神经成像.
- 生物标志物 生物标志物
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 血p-tau217是早期阿尔茨海默病 (AD) 病理学的可靠生物标志物.
- 从扩散加权成像中得到的皮层平均扩散度 (MD) 可能反映了神经退行性疾病的早期微观结构变化.
- 在认知不受损的个体中,血p-tau217和皮质MD之间的关系尚未研究.
研究的目的:
- 为了研究血p-tau217水平和皮质平均扩散度 (MD) 在认知不受损的老年人之间的关联.
- 确定p-tau217升高是否与特定大脑区域的微观结构变化有关.
主要方法:
- 从瓦莱卡斯项目队列中对1029名认知不受损的老年参与者的横截面分析.
- 使用LUMIPULSE平台测量血p-tau217水平;参与者被分类为ptau217+或ptau217-.
- 分析了扩散权重的MRI数据,以获得皮质灰质MD地图,并对年龄和性别进行语音智能统计分析.
主要成果:
- 而ptau217+组的年龄明显大于ptau217-组.
- 在对年龄和性别进行控制后,ptau217+组表现出显著更高的皮质MD.
- 在ptau217+组中,在双边中间时 (杏仁体,海马体) 和岛屿区域观察到升高的MD.
结论:
- 在没有认知障碍的个体中,可以检测到皮层MD变化,具有高血p-tau217.21的认知障碍.
- 这些观察到的MD变化发生在通常与AD神经病理学相关的大脑区域.
- 目前正在进行对该队列中MD变化的纵向分析.
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