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相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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生物标志物 生物标志物

Linda Zhang1, Jesús Silva-Rodríguez1, Eva Alfayate1

  • 1CIEN Foundation, Reina Sofia Alzheimer Center, ISCIII, Madrid, Madrid, Spain.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
概括

在没有认知障碍的个体中,血p-tau217水平升高与阿尔茨海默病 (AD) 相关区域的皮质平均扩散率 (MD) 增加有关. 这些发现表明,在认知能力下降之前可以检测到早期的微观结构变化.

科学领域:

  • 神经成像是一种神经成像.
  • 生物标志物 生物标志物
  • 阿尔茨海默氏症疾病研究研究

背景情况:

  • 血p-tau217是早期阿尔茨海默病 (AD) 病理学的可靠生物标志物.
  • 从扩散加权成像中得到的皮层平均扩散度 (MD) 可能反映了神经退行性疾病的早期微观结构变化.
  • 在认知不受损的个体中,血p-tau217和皮质MD之间的关系尚未研究.

研究的目的:

  • 为了研究血p-tau217水平和皮质平均扩散度 (MD) 在认知不受损的老年人之间的关联.
  • 确定p-tau217升高是否与特定大脑区域的微观结构变化有关.

主要方法:

  • 从瓦莱卡斯项目队列中对1029名认知不受损的老年参与者的横截面分析.
  • 使用LUMIPULSE平台测量血p-tau217水平;参与者被分类为ptau217+或ptau217-.
  • 分析了扩散权重的MRI数据,以获得皮质灰质MD地图,并对年龄和性别进行语音智能统计分析.

主要成果:

  • 而ptau217+组的年龄明显大于ptau217-组.
  • 在对年龄和性别进行控制后,ptau217+组表现出显著更高的皮质MD.
  • 在ptau217+组中,在双边中间时 (杏仁体,海马体) 和岛屿区域观察到升高的MD.

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结论:

  • 在没有认知障碍的个体中,可以检测到皮层MD变化,具有高血p-tau217.21的认知障碍.
  • 这些观察到的MD变化发生在通常与AD神经病理学相关的大脑区域.
  • 目前正在进行对该队列中MD变化的纵向分析.