生物标志物 生物标志物
Jeremy M Gu1, Laisze Lee2, Dana L Tudorascu2
1University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
美国国立卫生研究院工具箱认知电池 (NIHTB-CB) 在早期发现阿尔茨海默氏症 (AD) 病理学方面表现有前途. 皮层厚度 (CT) 和血p-tau217是与老年人认知功能相关的关键指标.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物研究 生物标志物研究
- 认知老龄化 认知老龄化
背景情况:
- 美国国立卫生研究院工具箱认知电池 (NIHTB-CB) 越来越多地用于阿尔茨海默病 (AD) 研究,以评估认知能力.
- 然而,它与AD生物标志物的相关性,特别是在临床前阶段,仍未得到充分研究.
研究的目的:
- 检查NIHTB-CB认知得分与非痴呆老年人的新型血和成像生物标志物之间的关系.
- 评估NIHTB-CB对早期AD相关病理学的敏感性.
主要方法:
- 258名参与者接受了临床分类,[11C]PiB-PET,MRI皮层厚度 (CT) 和血生物标志物分析 (BD-tau,p-tau217,p-tau181,p-tau231,Aβ42/40,GFAP,NfL).
- 线性回归模型分析了NIHTB-CB得分和生物标志物之间的关联,控制共变量.
- 对整个样本和认知正常 (CN) 和CN+子集进行了分析.
主要成果:
- 血p-tau217和皮质厚度 (CT) 在整个样本中显示出与NIHTB-CB得分的最强相关性.
- CT复合分数与流体和总认知复合分数有显著的联系.
- 在CN子集中,较低的CT,较高的PiB-PET SUVR和较高的p-tau217与较差的流体认知相关,而较高的p-tau181/231与更好的结晶认知相关.
结论:
- NIHTB-CB有效地揭示了认知与生物标志物的关系,包括血生物标志物,即使在认知上正常的个体中.
- 皮层厚度是反映神经退行对认知的影响的关键标记.
- 这些发现支持NIHTB-CB在识别与AD病理学相关的早期认知变化的实用性.
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