生物标志物 生物标志物
Sheelakumari Raghavan1, Jonathan Graff-Radford2, Jeffrey L Gunter3
1Mayo Clinic, Rochester, MN, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
在MRI上,后部汇合和皮层下多点白质超强度 (WMH-MS) 模式预测未来的大脑微血流 (CMB). 这一发现对于评估与大脑粉样蛋白血管病变 (CAA) 中抗粉样蛋白疗法相关的风险具有重要意义.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 生物标志物发现发现
背景情况:
- 后部汇合和皮层下多点白质强度过高 (WMH-MS) 模式被认为是脑粉样血管病变 (CAA) 的成像生物标志物.
- 使用WMH-MS预测未来的大脑微血流 (CMB) 对抗粉样蛋白治疗风险评估具有临床意义.
- 这项研究旨在确定WMH-MS的患病率及其在人口样本中预测事件CMB的实用性,考虑粉样蛋白和WMH负担.
研究的目的:
- 在以人口为基础的样本中确定阳性WMH-MS状态的流行率.
- 评估WMH-MS在预测事件CMB中的实用性.
- 为了评估WMH-MS的预测值,考虑到粉样蛋白和WMH负担.
主要方法:
- 来自梅奥诊所衰老研究的651名参与者接受了3T FLAIRMRI和T2*加权的GRE序列.
- 视觉读取评估WMH使用Fazekas尺度和WMH-MS严重程度.
- 单变量和多变量逻辑回归分析了WMH-MS和事件CMB之间的关联,并调整了共变量.
主要成果:
- 与没有发生CMB的参与者相比,WMH-MS模式在患有事件CMB的参与者中 (20.8%) 发生的频率明显高 (2.8%).
- 在调整年龄,性别,APOE4,高血压,先前的CMB和粉样蛋白状况后,WMH-MS,但不是Fazekas得分,与发生的CMB独立相关.
- 老年和男性性别也预测了发生的CMBs.
结论:
- 在FLAIR-MRI上视觉识别的WMH-MS模式可以预测一般人群中发生的CMB.
- WMH-MS模式可以作为CAA的有用的成像生物标志物.
- 需要进一步的研究来评估WMH-MS作为临床试验中的生物标志物用于粉样蛋白相关的成像异常.
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