生物标志物 生物标志物
Edric D Winford1,2,3,4, Benjamin D Huber1,2,3,5, Jessica Mazen1,2,3,5
1Columbia University, New York, NY, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
患有阿尔茨海默氏症 (AD) 的父母与中年成年人中较高水平的外周炎症有关. 这些炎症标记因性别和种族而异,表明对阿尔茨海默病的个性化风险评估.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 周围炎症是阿尔茨海默病 (AD) 发展和进展的已知危险因素.
- 衰老会增加炎症,可能是AD发病之前的.
- 父母患有阿尔茨海默氏症的病史会增加一个人患这种疾病的终身风险.
研究的目的:
- 为了调查父母患有阿尔茨海默氏症的病史是否与中年成人外周炎症的增加有关.
- 为了确定患有阿尔茨海默氏症父母史的个体与没有阿尔茨海默氏症的个体相比,表现出更高水平的促炎细胞因子.
- 检查这些协会跨越不同的种族和种族群体.
主要方法:
- 分析了1043名非西班牙裔白人,非西班牙裔黑人和西班牙裔成年人的后代研究.
- 通过诊断共识会议来确定父母的AD状态.
- 使用Luminex技术测量血化基因和细胞因子度,并根据年龄,性别,种族,种族和APOE基因型进行调整.
主要成果:
- 患有阿尔茨海默氏病父母病史的参与者表现出较高的Eotaxin水平和较低的G-CSF,VEGF-A和IL-27.
- 观察到的特定差异:黑人个体的IL-18高,白人个体的EGF高,父母有AD史.
- 患有阿尔茨海默氏病的父母有过阿尔茨海默氏病史的妇女,IFna2,IL-12p70,sCD40L和IL-18的水平较高.
结论:
- 父母患有阿尔茨海默病的病史与周围炎症标志物升高有关.
- 观察到的父母阿尔茨海默病史和炎症之间的关联因性别和种族/种族而异.
- 这些发现突出了AD风险中受遗传学和人口统计学影响的潜在炎症途径.
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