生物标志物 生物标志物
Oladotun V Olalusi1,2,3, Tolulope O Akinyemi4, Andrea L Benedet5
1Neuroscience and ageing research unit, Institute of Advanced Medical Research and Training (IAMRAT), College of Medicine, University of Ibadan, Ibadan Nigeria, Oyo, Nigeria.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
手握强度与老年尼日利亚人的神经退行指标有关. 这种物理测量可能有助于选阿尔茨海默病风险和其他生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 生物标志物发现发现
背景情况:
- 血生物标志物和身体脆弱性测量有助于认知查和诊断.
- 手握强度 (HGS) 表示身体健康和认知能力下降.
- HGS和阿尔茨海默病 (AD) 血生物标志物之间的联系是未知的.
研究的目的:
- 调查HGS与AD和神经退行症的血生物标志物之间的关联.
- 探索HGS作为潜在的认知障碍非侵入性查工具.
主要方法:
- 尼日利亚的长度社区基队列研究 (VALIANT).
- 招募了1036名老年人,评估了认知功能,并测量了血生物标志物 (GFAP,NfL,p-tau217,Aβ42/40).
- 使用多重线性回归来分析HGS和血生物标志物之间的关系,调整共变量.
主要成果:
- HGS与血p-tau217,Aβ42/40和NfL之间显示出一个独立的关系.
- 在回归分析中,在HGS和所有测量的血生物标志物之间发现了显著的关联.
结论:
- 手握强度与尼日利亚老年人的神经退行性血标志物独立相关.
- HGS和血生物标志物可以作为补充查工具,用于识别患有AD和相关痴呆症 (AD/ADRD) 风险的个体.
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