生物标志物 生物标志物
Claudia Aponte1,2, Laura García3,4, María José Hidalgo Ramírez5,6
1Grupo Neuropsicología y Conducta, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
图表指标显示,PSEN1 E280A突变的无症状载体中大脑连接性发生变化. 在非携带者中,中间中心性更高,这表明在阿尔茨海默氏症早期阶段的局部网络差异.
科学领域:
- 神经成像是一种神经成像.
- 网络神经科学 网络神经科学
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 图表指标分析了阿尔茨海默病 (AD) 的功能连接.
- 与对照组相比,AD和MCI患者的节点和全球图表指标不同.
- 自体主导性阿尔茨海默病 (ADAD) 突变携带者可能在疾病阶段表现出不同的图表指标.
研究的目的:
- 在默认模式网络 (DMN) 中调查图形度量特征.
- 专门检查PSEN1 E280A突变的无症状携带者.
主要方法:
- 从32个无症状载体 (aC) 和25个非载体对照 (nC) 获得的rs-fMRI数据.
- 使用CONN工具箱进行预处理的数据;使用Schaefer地图 (79ROI) 提取的DMN和休息状态网络 (RSN).
- 使用GRETNA工具箱在稀疏度值 (0.05-0.5) 上计算的图表指标;统计分析包括Wilcoxon测试和带Bonferroni校正的线性混合模型 (LMM).
主要成果:
- 学历在各组之间有显著差异 (p < 0.001),但年龄和性别没有.
- 在nC中,中间中心性 (Bc) 比aC更高 (p=0.0051).
- 线性混合模型显示了节点图度量交叉点的群体差异,聚类系数,中间中心性,局部效率和中心度度倾斜在aC和nC之间有所不同.
结论:
- 间隔中心性区分无症状携带者 (aC) 和非携带者 (nC),在nC中较高.
- 这表明局部网络组织,其中节点在nC中更为中心,可能反映了aC的早期病理生理变化.
- 观察到的aC局部变化可能代表DMN重组,以保持认知功能,尽管潜在的AD相关变化.
相关概念视频
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