生物标志物 生物标志物
Huitong Ding1, Xavier Serrano1, Edward Searls1
1Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
老年人的重复性头部冲击 (RHI) 与数字认知测试中的更大变化有关. 患有RHI的个体表现出更明显的波动和较少的实践效益,突出了在认知评估中考虑RHI史的必要性.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 运动医学 运动医学
背景情况:
- 重复的头部冲击 (RHI) 与认知衰退和神经退行性疾病有关.
- 传统的认知测试可能无法检测RHI的微妙缺陷.
- 数字测量可以提供更敏感的RHI相关认知变化的检测.
研究的目的:
- 调查RHI对数字神经心理测量的稳定性的影响.
- 为了比较具有和没有RHI史的认知完整的老年人之间的认知性能变化.
主要方法:
- 使用来自波士顿大学阿尔茨海默氏病研究中心数据的试点研究.
- 根据2021年NINDS TES研究诊断标准确定RHI状态.
- 防御自动神经行为评估 (DANA) 数字测量分析了个体内变化 (变化系数).
- 曼-惠特尼U测试和线性混合效应模型比较了RHI和非RHI组之间的变化.
主要成果:
- 58名认知完整的老年人 (10RHI) 参与.
- DANA表现的日复一日波动一般很小.
- 患有RHI的个体在Go/No-Go和简单响应时间等任务中表现出明显更大的变化.
- 在程序响应时间任务中,RHI组观察到显著的相互作用效应.
结论:
- 数字认知测量显示总体稳定性,但在RHI的老年人中显示出增加的变化.
- 患有RHI的人似乎从数字任务的重复练习中获益较少.
- 在老年人群中,RHI史是解释纵向认知评估的关键因素.
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