生物标志物 生物标志物
1Clinical and Translational Science Institute, Tufts University, Boston, MA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
SpeechDx正在创建一个大型语音和临床数据数据集,以开发阿尔茨海默病 (AD) 的新预后生物标志物. 这将有助于预测认知能力下降,并指导早期干预策略.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物发现发现
- 计算语言学 计算语言学
背景情况:
- 血液生物标志物可以识别粉样蛋白病理,但不能预测症状性阿尔茨海默病 (AD) 的进展.
- 预后生物标志物对于识别可能受益于早期干预的个体至关重要.
- 语音衍生生物标志物提供了可扩展的潜力,但需要大量的注释数据集.
研究的目的:
- 建立一个全面的,协调的语音纵向,生物标志物和临床数据数据集.
- 促进开发用于阿尔茨海默病的预后语音和语言生物标志物.
- 为了使机器学习模型训练能够预测认知衰退.
主要方法:
- SpeechDx是一项纵向观察性研究,在美国,澳大利亚和西班牙招募了多达3000名参与者.
- 参与者通过专门的应用程序完成季度远程语音和语言任务.
- 临床站点收集纵向生物标记数据 (血液,MRI,神经心理评估) 与语音样本配对.
主要成果:
- 通过协调来自不同认知频谱参与者的语音,生物标志物和临床数据来创建SpeechDx数据集.
- 计划于2025年开始向合作伙伴发布临时数据.
- 全数据集预计将在2028年底完成.
结论:
- SpeechDx正在建立一个重要的资源,以推进阿尔茨海默病的预后生物标志物研究.
- 该研究的协调数据库将加速基于语音的AD生物标志物的开发.
- 这个倡议支持创建可扩展的工具来预测认知衰退.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516