痴呆症护理研究和心理社会因素
Tara C Carlisle1, Kavita V Nair2, Stefan H Sillau3
1University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
来自专门诊所的现实世界数据显示,像lecanemab这样的抗粉样类疗法 (AAT) 与临床试验中的不同方式被使用. 增加痴呆症专家可以改善患者获得AAT评估和管理的机会.
科学领域:
- 神经退行性疾病 神经退行性疾病
- 临床神经学 临床神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗粉样蛋白疗法 (AAT) 的临床试验并不完全代表现实世界患者的经验.
- 神经退行性疾病高级治疗 (ATND) 诊所提供了一个独特的环境来研究AAT利用.
研究的目的:
- 在ATND诊所记录AATs的特性和使用情况,特别是lecanemab.
- 分析患者的人口统计,诊断方法和与lecanemab治疗相关的结果.
主要方法:
- 从ATND诊所的电子医疗记录的回顾性审查 (2024年4月 - 2025年1月).
- 收集的数据包括患者人口统计数据,诊断评估 (MRI,腰部穿刺,PET),lecanemab使用情况,以及与粉样蛋白相关的成像异常 (ARIA).
主要成果:
- 评估了96名患者;19.8%的患者正在接受lecanemab输注,而28.1%的患者拒绝接受治疗.
- 莱卡尼马布下降的常见原因包括同卵性APOE4状态 (37.0%) 和对疗效和治疗负担的担忧.
- 两名患者经历了ARIA;10个月的平均输液量为12.2.
结论:
- ATND诊所提供了关于AAT经验的宝贵现实数据.
- 扩大痴呆症专家的能力对于提高患者获得AAT评估和管理的机会至关重要.
更多相关视频
08:36The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living
Published on: July 28, 2022
4.3K
10:13Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
Published on: February 14, 2014
14.1K
相关概念视频
01:30Dementia
482
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
482
01:29Psychological and Sociocultural Causes of Schizophrenia
438
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
438
01:26Alzheimer's Disease: Overview
1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
01:22Alzheimer's Disease: Treatment
744
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
744
01:30Cognitive Development During Adulthood
740
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
740
01:29Documentation in Long-Term and Home Healthcare Setting
1.4K
Documentation in long-term care facilities and home healthcare settings is crucial for ensuring continuous, coordinated, and comprehensive care for patients. Each setting has its specific documentation processes and tools:
Long-Term Care Facilities
Long-Term Care Facilities
1.4K