痴呆症护理研究和心理社会因素
Alexa Goldstein1, Erin Anita Krahn2, Neguine Rezaii3
1Frontotemporal Disorders Unit, Massachusetts General Hospital, Boston, MA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
频繁的远程医疗认知测试对于接受lecanemab的阿尔茨海默氏病 (AD) 患者来说是可行的,显示了适度的遵守,并建议针对抗粉样蛋白疗法的新监测模型.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 临床试验 临床试验
背景情况:
- 越来越多的抗粉样蛋白疾病修饰疗法 (DMT) 处方,如阿尔茨海默病 (AD) 的lecanemab.
- 需要频繁和深入的患者监测,以跟踪治疗期间的认知,行为和功能变化.
- 这项研究调查了基于远程医疗的认知测试协议的可行性,用于lecanemab的AD患者.
研究的目的:
- 对接受lecanemab的AD患者进行频繁远程认知测试协议的可行性进行评估.
- 评估患者对远程医疗认知评估的遵守和参与.
- 探索远程监测作为AD DMTs患者的模型的潜力.
主要方法:
- 对18名阿尔茨海默症患者进行的前性观察性研究,对lecanemab.
- 通过REDCap.com填写的验证问卷 (阿姆斯特丹 IADL,NPIQ) 已经得到验证.
- 每3个月进行一次远程医疗认知评估,包括使用替代形式修改的ADAS-Cog.
- 每月通过SurveyLex平台与Zoom进行远程测试,用于记忆,语言和执行功能测试.
主要成果:
- 34名参与者接受了查,53%的参与者被录取 (平均年龄为67.2岁,55%是女性).
- 报名参与者的平均MoCA得分为19.2.2.
- 基线和3个月的会议平均为67分钟;每月的会议平均为35分钟.
- 61%的参与者在3个月后仍然注册;由于测试需求,有5名参与者退出.
结论:
- 经常进行远程认知测试,对接受莱卡尼马布治疗的阿兹海默症患者是可行的.
- 适度的遵守 (61%在3个月) 表明这种监测模型的潜力.
- 建议每月进行远程评估,作为监测接受AD DMT的患者的新方法.
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