Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Effect of angiotensin II and angiotensin II type 1 receptor antagonist on the proliferation, contraction and collagen synthesis in rat hepatic stellate cells.

Chinese medical journal·2008
Same author

[Determination of nicotinamide in formula milk powder using liquid chromatography-isotope dilution mass spectrometry].

Se pu = Chinese journal of chromatography·2008
Same author

In vivo tracking of superparamagnetic iron oxide nanoparticle-labeled mesenchymal stem cell tropism to malignant gliomas using magnetic resonance imaging. Laboratory investigation.

Journal of neurosurgery·2008
Same author

Enhancement and broadening of extreme-ultraviolet supercontinuum in a relative phase controlled two-color laser field.

Optics letters·2008
Same author

Screening and breeding of high taxol producing fungi by genome shuffling.

Science in China. Series C, Life sciences·2008
Same author

Reversible self-association of a concentrated monoclonal antibody solution mediated by Fab-Fab interaction that impacts solution viscosity.

Journal of pharmaceutical sciences·2008
Same journal

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

生物标志物 生物标志物

Yingren Mai1, Zhiyu Cao1, Qun Yu2

  • 1The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
概括
此摘要是机器生成的。

这项研究揭示了阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 的显著代谢变化. 血清中的特定脂质和氨基酸变化与认知能力下降有关,为早期AD和MCI诊断提供了潜在的生物标志物.

更多相关视频

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

相关实验视频

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

科学领域:

  • 神经科学是一个神经科学.
  • 代谢学 代谢学 代谢学
  • 生物化学 生物化学

背景情况:

  • 阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 是导致痴呆的主要原因,这给诊断和治疗带来了挑战.
  • 代谢物在AD和MCI的发病过程中至关重要,但脂质代谢的变化仍然不太清楚.

研究的目的:

  • 与认知正常个体相比,识别和描述AD和MCI患者血清中的代谢变化.
  • 研究这些代谢变化与认知功能的关联,并开发诊断生物标志物.

主要方法:

  • 使用超高性能液体染色学-三重四极质谱学的定量,有针对性的代谢学.
  • 来自AD (n=22),MCI (n=19) 和认知正常 (CN) (n=19) 个体的血清样本的分析.
  • 使用机器学习算法 (RF,SVM,GB,LR) 来识别生物标志物面板.

主要成果:

  • 与CN相比,在AD血清中确定了32种不同代谢物,在MCI血清中确定了49种不同代谢物.
  • 参与脂肪酸,氨基酸和脂代谢的代谢物与认知评分 (MMSE,ADAS,MoCA,CDR,AVLT,TMT) 有显著的关联.
  • 开发了10个AD代谢物和13个MCI代谢物的面板,可以准确地区分患者组和CN个体.

结论:

  • 血清代谢干扰,包括脂,甘油脂,自由脂肪酸和乙烯基胺,始终与AD和MCI病理和进展有关.
  • 这些已识别的代谢生物标志物对阿尔茨海默病和MCI的早期诊断和潜在治疗策略有前途.