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使用HiBiT系统识别CARM1降解因子,用于向癌症治疗.

Megan Bacabac1, Mingshan Hu1, Fabao Liu1

  • 1McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.

Journal of medicinal chemistry
|December 26, 2025
PubMed
概括

研究人员确定了天然化合物,kusunokinin和exostemin,这些化合物降解了与协活性剂相关的阿金氨基甲基转移酶1 (CARM1). 这些化合物显示出开发新的癌症疗法,具有改进的类似药物的特性.

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