无手术阶段1a NSCLC 的肺切除结果
Sameer Rehman1, Shreyas Naidu2, Raja Shehayar Mehdi3
1Thoracic and Interventional Radiology, Desert Radiology/Radiology Partners, Las Vegas, NV; Interventional Radiology, Centennial Hills Hospital, Las Vegas, NV.
Journal of vascular and interventional radiology : JVIR
|December 26, 2025
概括
皮肤透结冰疗法在无法进行手术的患者早期肺癌中显示出有前途的结果. 这种微创治疗提供了有效的局部控制和良好的安全性,支持在精选患者中使用.
科学领域:
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
- 干预性放射学 干预性放射学
背景情况:
- 非小细胞肺癌 (NSCLC) 是癌症死亡的主要原因.
- 患有早期NSCLC的医疗不可操作的患者的治疗选择有限.
- 穿皮切除技术正在成为外科手术的替代品.
研究的目的:
- 评估通过皮肤冷化治疗1a期NSCLC的疗效和安全性.
- 评估医疗上不可手术的患者的局部控制和生存结果.
- 为了确定治疗失败的预测因素.
主要方法:
- 对176名活检证明的第一阶段a NSCLC 患者的回顾性分析.
- 患者在CT指导下接受了皮肤穿透式冷化.
- 使用标准化三重冷解方案,通过CT和PET成像进行随访.
主要成果:
- 一年和三年当地无进展生存率分别为91.8%和89.4%.
- 一年后的总体生存率为100%,三年后为94.7%.
- 肺胸炎是最常见的不良事件 (17.6%);没有报告住院死亡.
结论:
- 皮肤透冷是有效的局部控制在医学上不可操作的1a期NSCLC.
- 这种手术具有良好的安全性,特别是在小于2.0厘米的瘤中.
- 结冷处理需要进一步研究,作为这组患者的首要治疗方法.
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