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使用生物可用性胃肠道消化模型评估生物基微塑料金属对人类健康的风险

Javier Terán-Baamonde¹, Rosa-María Soto-Ferreiro¹, Elia Alonso-Rodríguez¹

¹Universidade da Coruña, Grupo Química Analítica Aplicada (QANAP), Instituto Universitario de Medio Ambiente (IUMA), Centro de Innovación Tecnológica en Edificación e Ingeniería Civil (CITEEC), 15001, A Coruña, Spain.

Environmental pollution (Barking, Essex : 1987)

|December 26, 2025

概括

像PLA和PHB这样的生物塑料可以释放金属. 生物可用性,而不仅仅是生物可访问性,是评估这些微塑料对人类健康的风险的关键.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
材料科学材料科学材料科学

背景情况:

生物基塑料被推广为传统塑料的可持续替代品.
评估生物基塑料对人类健康和环境的影响至关重要.
来自生物基材料的微塑料 (MP) 可能会炼金属.

研究的目的:

评估来自常见生物基微塑料的12种金属的人类生物可用性:聚乳酸 (PLA),聚基酸 (PHB) 和聚3-基酸-co-3-基酸 (PHBV).
为了比较基于生物可访问性和金属生物可利用性的人类健康风险,来自老化和金属载荷生物基MP的金属.
为了确定不同生物基塑料类型的不同与金属相关的行为.

主要方法:

使用了采用透析膜的统一生物可访问性方法 (UBM) 修改的体外胃肠道程序.
模拟肠道吸收以确定金属的生物可用分数.
评估原料,海洋老化和实验室金属吸附生物基MPs.

主要成果:

原始和海洋年龄的MPs没有致癌或非致癌风险.
基于生物可访问性,金属装载的MP显示出非致癌风险 (Cd,Co,Sb) 和致癌风险 (Cr).
生物可用性评估限制了Cd和Co的风险,表明它是一个更可靠的人类健康风险指标.

结论:

生物可用性是比生物可访问性更准确地衡量生物基MP中金属对人类健康的风险.
含有金属的生物基MPs可能会对健康造成风险,特别是Cd,Co和Cr.
不同的生物基塑料类型表现出独特的金属结合和漏特性.

关键词:

生物基塑料是生物基塑料.生物可访问性生物可访问性生物可用性生物可用性评估健康风险评估健康风险在体外胃肠道消化过程中.金属金属金属

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