后顶层皮质根据精神病现象型调节感知决策
Francesco Scaramozzino1, Ryan McKay1, Nicholas Furl1
1Royal Holloway, University of London, UK.
Neuropsychologia
|December 26, 2025
概括
在后壁皮层 (PPC) 上的重复性跨体磁刺激 (TMS) 改变了健康个体的决策,但不是那些患有精神病的表型的人,这表明在精神病中改变了PPC兴奋性.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
背景情况:
- 精神病现象型与减少数据收集和改变感官精度有关,特别是在涉及后壁膜皮层 (PPC) 的任务中.
- 通过1Hz重复性横磁刺激 (TMS) 调节的后壁皮层 (PPC) 刺激性,研究了它对这些行为模式的差异性影响,高与低精神病现象类型.
研究的目的:
- 调查使用重复性跨磁刺激 (TMS) 调节后壁皮层 (PPC) 刺激能力是否对高与低精神病现象型的个体的感官精度和数据收集决策产生不同影响.
- 测试假设妄想和幻觉特征对TMS对感官精度 (漂移率) 和决策值的影响是温和的.
主要方法:
- 共有68名参与者被分为两组,在正确的PPC上接受TMS或假TMS.
- 使用随机点运动 (RDM) 和珠子任务进行了性能比较.
- 使用分层漂移-扩散模型来估计漂移率 (感官精度) 和决策值,检查与妄想和幻觉现象型的相互作用.
主要成果:
- 在随机点运动 (RDM) 任务中,TMS在低精神病态表型组中增加了决策值,这种效应在高精神病态表型组中不存在.
- 漂移率在具有较高妄想表型的参与者中减少.
- 没有观察到对珠子任务的显著影响.
结论:
- 这些发现表明后壁皮质 (PPC) 在决定在感知推理过程中终止数据收集时起因果作用.
- 精神病表型组中对决策值缺乏TMS影响,这表明了关于PPC刺激性在精神病决策背后的神经机制中的作用的新假设.
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